My character just surpassed $2 billion in lifetime GTA$
To this day I still keep my Bunker and Nightclub goods running. I do not do any other businesses.
Before next-gen came out I used to AFK a lot with those 2 businesses, hence the total time played.
I mostly stick to Heists these days (both for my own Career Progress as well as with randoms) and have been purchasing a ton of cars from LSCMs.