Travel during pre-completion OPT application

Currently applying for OPT before graduation in December. I just got an OPT issued I-20 in the process of the application. I have plans to travel home between end of classes and final exams in November. I am doing the rush processing for OPT and was wondering if there would be an issue returning to the US before OPT is approved. It would still be before graduation but worried the OPT specific I-20 would cause issues on return. Surely they won't expect me to have my EAD card. Should I wait to apply after I return from the trip? Any help would be appreciated.