Could too many addon dlc cause issues loading textures?

My game has been running fine until recently and I’ve spent the past few days troubleshooting what could be the issue. What happens is that upon starting the game, everything is fine. And then about 20-30 mins into gameplay, severe pop-in starts to occur and then finally textures fail to load all over. I’m wondering if the recent Agents of Sabotage update might be one cause of this, on top of the many addons I’ve installed, since this has never happened before.