Can chameleons like some people and not others?

My wife practically cried for me to get her a $500 panther chameleon lizard that i initially said hell naw too.. well, the lizard lets me pick him up and pet him, etc. but when she tries he flares out, opens his mouth and hisses despite her being the one that wanted him lol. Do chameleons hate on certain people? Do certain colors set them off?